I have several calibers and haven't noticed that if I do my part that one kills more DEAD than the others but I do have one rifle that fits me well, has a nice slender stock and will flat out shoot and it's a 280 Remington CDL. When I hunt fields I carry it topped with a Leupold Boone & Crockett reticle that is spot on out to 500 yds.

HMM-161, HMM-364
Semper Fi Brothers