Tom,
In my experience, it kill's 'em deader'n a doornail - it's the aftermath on the cutting table with copious amounts of strawberry jello / waste.
I don't see a lot of difference in destructiveness between most .243 bullets, and consider the 100 partition to be as destructive as the rest. That front end is wicked. I only shoot maybe a couple of deer a year, on average, so FWIW...
Accuracy and performance, my top 3 picks are the 85 bthp, the speer 90, and the BT95...
