I have shot exactly one giraffe,an old female,she was the biggest in her group,I had two rifles that trip,a Krieghoff double rifle in 500/416 & a Dakota African in 338 Lapua,I used the 338 on the giraffe,the load was Tsx 250 gr @ 2750,range was about 125 yrds,I opted for a heart shot,she took off at the shot,but was down within maybe 40-50 yrds,no more shots needed,I have killed a lot of game with that load,hit's like a hammer.