Really can not go wrong with either of those two plus a good “handful” of others. I took a Blaser R92 with both those two barrels — the ‘06 and the 375 — to do the plains game. I started with the 375 and my 270-gr TSX handload, had a ball with it, and never did switch to the ‘06 for which I had a 168-gr TSX hand-load and which was my intention.. Both are great.
