I've killed mulies with both at about the same distance of 150 yds. Whelen was a 250 Speer at 2500 fps and the 300 was a 180 Partition at 3000 fps. The 250 Speer acted like a hand grenade in the body and my guide said he'd never seen more damage to an animal. Took one step. 300 zipped thru with a perfect 1" hole thru both lungs and it did the usual 100 yd death sprint. I went back to my 270.