All good advice here, cant disagree with any. I personally went from a .25-06 to a 7 Mag 15 years ago because I didnt like the way the wind pushed my 100 gr. Hornady spirepoints around. I changed from the 7 Mag to a 6.5 Creed last year because of boredom--the 7 Mag was just too good at its job. The 6.5 Creed shoots a longer 140 gr. bullet at a much slower muzzle velocity with less weight, less recoil, and better wind bucking ability, and has just the right amount of energy--not too much. Most of my 7 Mag kills went through and through. That said, I think mirage and wind are the two biggest factors in antelope shooting. 300 yards is about the practical limit for me, because holding over 27 inches and into the wind 22 inches at 400 yards in a 20 knot crosswind is fine for paper, but I dont feel confident enough to risk wounding an antelope with that kind of shot. Bottom line is its all personal preference. Use whatever makes you feel good. They all work.