.257 AI, .257 Rob, & 6mm-250 have all proven effective for me.

.22-250, .223, .243 Win, 6mm Rem, .25-06, .270, .280, 7-08, 7x57, .308, .30-06, 8x57... can’t think of many cartridges I wouldn’t think were solid choices for pronghorn!

Originally Posted by MedRiver
In my mind something in the 6mm class shooting a bullet with a decent BC is hard to beat if purpose building/selecting an "antelope" rifle.



Totally agree with that; a 6mm-06 with fastest twist you can find would be a tough one to beat. 6mm Creedmoor for factory.