I have used and liked the .250 Savage, .257 Roberts and .25-06. My primary interest in the .25 calibers is a deer / antelope rifle used on the great plains. For that the .25-06 is clearly superior for my needs. I don't own a .250 or .257 any more. I found my one .257 Roberts ( a Model 70 Win. FWT push feed) very fussy to load for, and only a couple bullets would shoot well. 2800 fps with 120's was uninspiring but deadly at reasonable ranges. The three .250's that I owned, 2 Savage 99's and a Ruger 77 were hampered by case capacity / bullet speed and /or twist rate and bullet weight that they would shoot. The .25-06 accurately delivers a 100 -120 grain bullet at speeds that don't require hold over at the ranges I choose to hunt. Perfect. My Sako AV 25-06 isn't leaving my hands any time soon.