Wesley2 said he had good luck with the 6mm Gamechangers on deer. I had a very different experience with the 165s out of a 280 Ackley on a bull elk. Ranges during my rodeo were 175 to 390 yards and 3 out of 4 shots were tight behind the shoulder. No bullets reached the ribs on the off side and no bullets were recovered. Muzzle velocity was 2975 FPS. All three shots appeared to be blow-ups. The bull staggered 75-100 yards into some quakies and was finished with a shot to the neck. I wouldn’t wish the experience on anyone.