I’ve got a 270, 300 & 340 Weatherby rifles and have found that the power isn’t often needed now that optics have the capability of stretching trajectories in ways I never imagined as an old school hunter. Velocity used to be the only way to shoot far - now it’s about BC. Look at your particular rifle as a bullet launcher only - head stamps are yesterday. Took me several years to figure that out.

Long story short - I went 338-06 and haven’t looked back. Lots of good info both here & online. Not (much) better than a 30-06 with 200 grain partitions but seriously - not much is - however the 338-06 can shoot the grand 250gr Nosler Partition which can literally kill anything. Just my .02

Let us know what you go with