This notion of penetration is valid, but only sometimes. You have to stop the threat, that does not require penetration per se, it requires a vital hit (heart, CNS, pelvis). We all know that, same for two legged vermin. Penetration does not make that hit any easier. It just means that if the shot angle isn't exact, you stand a better chance of getting to the vitals.
Hell yes to the bolded quote. This notion of penetration is valid
always and for the very reason you stated, to reach and destroy vital organs, CNS, bones, ect. Shot placement is King, penetration is Queen and all else is gravy.