I have used both bullets and shot a number of roe bucks with them using a 5,6x50R a cartridge which, roughly throws them about 70-100 fps faster than a .223R
Both killed well but I prefered the Hornady 55gr over the 70gr Speer, which I found to be too soft for my taste, circumstance that would worsen at 22-250 velocities. The 55gr Hornady shot better, too.
So, between the two I would recommend the 55gr Hornady.
My very favourite in my 1:8" 22-250, though, is the 77gr TMK whose use I owe to Formidilosus who kindly shared his vast experience with it. It is a superb killer and has proved extremely accurate in my gun. It produces an amoiunt of damage and penetration that rationale can not explain.
Alvaro
