I’ve shot a handful of deer with the 55hornady with 22-250. It worked very well. Never had one shoot clear through on broadside shot but the bullets are always on the skin on the off side. I shot a couple with the plain Jane hornady 60 grain bullet and they all shot completely through the deer. I’d like to try the 62TTSX and the Speer gold dots as well. I’m guessing they’d be great. But the hornady bullets are cheap and available and they’ve been working well for a long time. Good luck.