Gunner; thanks for starting this interesting and informative thread.

I do not have extensive experience with high velocity .257s but I did hunt for several years with .25-06. I shot a WT buck at well under 100 yards at a steep angle with the 115 original X bullet.

The bullet was recovered and had lost all of its petals, the metplat measured .41? .42? I would have no concerns with a high velocity 40 + calibre flat nose solid.

I think you would do well with the tip less TTSX (TTTSX? smile )

Maybe try shooting some into test media at 25 yards and see how they do? Not a 100% reality test but it can give a good idea what to expect.