For little jobs like gutting a skinning a deer I just use my pocketknife. I guess my definition of a lot of work is different than some because I can clean up the hinge and liner on my pocketknife in about 3 minutes at the sink.
For bigger jobs like skinning and quartering an elk or moose I generally use 2 knives and they happen to be fixed blades. I have done an elk with my pocketknife though.
I was with a guy who had one of the replaceable blade knifes when he skinned a bear once. Nothing majorly catastrophic but he did put some extra holes in the hide. I think there may be such thing as too sharp for general use.
