It's strange to me that people will admit to seeing a difference in 223 vs 22-250 on deer; I've used the 221FB all the way up to .375h&h and most things in between and could not tell a difference. They just died. Not at all implying that they are wrong, just stating that I couldn't detect a difference either way. Course I'm shooting them <250 yds. Maybe that's what seperates the two.