We have used a 222 and 22-250 on dozens of deer/antelope.,
If I was to pick one, it would be the 250.
Used the 53gr TSX out of a 1:14 twist 22-250 it it works great.
The 222 is a 1:9 twist and have used 65 gr Sierra, and 55gr GMX.
Had to re barrel the 22-250 and went with a 1:8. Have not used it on anything yet.
