There is no comparison to a hot loaded 10mm and a hot loaded 44 mag. Not even 100/65. 10mm is a pussy cat loaded at its max with a 220 hc. Try a 44 mag loaded to the max with a 300 hc over a case full of 110. Its not close. Depending on the gun, a hot loaded 44 mag starts into recoil that makes you have to pay attention to what youre actually doing. Ive owned dozens of both and have put thousands of rounds down range