I own a first run M610 5" and a rebarreled M29-2 5", both with the full lug so pretty close weight wise and there is no question that a legitimate 240 gr load from the 44 is a fair bit stiffer than a legitimate 180 gr load from the 10. I chose the weights that I have shot and tried to keep apples to apples with traditional loads in both. Yeah 340's in the 44 and 220's in the 10....