I'm no handgunner, but we seem to ignore a lot of history. I think it was called the Thompson-LaGarde Tests of 1904. Anyway I'll spare you the details...but only one cartridge tested exceeded the .45 ACP...it fired a 265 gr lead round nose at 650 fps...it was called the .455 Eley/Webley. Accounts of British officers serving in trouble spots around the world verified it's effectiveness on the bloody wogs. Many of whom were on drugs. So I suppose you could say that velocity is a small factor in lethality.
