My hunting group's weapons of choice have been 270 Win, 308 Win, 30-06 and 7mm Rem Mag. One thing that stand out between those calibers is we all use a 150 grain to 180 grain bullets. We hunt meat so cows are the target, and those weight bullets put them down efficiently. we all are resident hunters but if I was paying for a non-resident license and maybe getting only one shot in a 6-7 day hunt at long range at that nice bull, I sure as hell wouldn't be messing around with a 243.
