My first experience with the .25-06 took place 20 years ago, on a "cull" hunt in Ireland, of all places. It was hosted by Heym Firearms of Germany on the estate of the last living British earl in Ireland. The head guide was a well-off plumber named Liam Kenehan, who leased the deer-hunting rights from the earl.
I ended up using Liam's straight-pull Heym .25-06, which he'd used to take fallow and red deer out to 600 yards, thanks to the multi-dot Schmidt & Bender on the rifle. I didn't shoot anything that far, but did take one female fallow deer at 450--which ain't all that far these days, but was the longest shot encountered during the cull.
That was using Remington 120-grain Core-Lokt factory ammo, which is what Liam had used to take a big red stag at 600. But as we all know now, that's a totally inappropriate choice of not just cartridge but ammo and bullet. Though will note that central Ireland is less windy than many places, including the Campfire....
