Honestly, between my son and I we've topped over 200+ animals with 25-06's over a 20 year span here in Texas and never thought we needed anything else. Most of these were taken in West Texas, culling large ranches for exotics and hogs and yes, a lot were head shots at closer ranges. For the 200-400 yard shots, the only thing that mattered was shot placement and the bullet used.
Know having said that, I just recommended to a new 26 year old hunter that's like a second son to me to buy a 6.5 Creedmore for hunting here in Texas instead. Do I think it's "better" than the 25-06? No, I don't but twist rates, ammo selection(he doesn't reload), and inherent accuracy of the CM make it a "no brainer."
Hope this helps.
BBQ
