I suspect the 243 would work as well as anything. Only thing that would keep me from it is the animals I might run into looking for that cat. 308 with a 180 should work vey well in fact even with a 165gr. But dangerous game country is not the place to experiment with smaller cartridges and what might be actually possible! If I was to go there looking to shoot a leopard I'd take my largest cartridge rifle with a heavy for caliber bullet! That would be my 30-06 with a min 180 gr bullet. That is assuming I'm shooting it very well. A miss placed shot from any rifle with any bullet would not be something I'd look forward to. I think the real answer depends on the bullet's available in the cartridge you take. Take that 243 even with a 100gr bullet and you are looking for trouble and just might find it! If I handled magnums well I'd look at something like a 338 magnum and 250gr bullet's. Better to over react in a bad situation than under react!

Last edited by DonFischer; 03/21/24.