Not sure if I’ll ever do a leopard hunt but if I do I’ve often thought about my favorite 308 ( that’s been to Africa a couple of times) and loading it with the lowly 150 hornady interlock. I would of course ask my ph his opinion but he too has killed many with a 243. I do know that despite his very strong fondness for TSX bullets for most hunting in Africa he strongly dislikes them for leopards. He and his father have been baiting leopards very successful for probably 50 years or more so I tend to listen to him on that subject. Personally I can’t imagine your 180AB not being absolutely suitable but as others have said I might consider a lighter bullet at a bit higher velocity. I’d rather have a bigger hole in the hide to contend with v a leopard I never found!good luck on your hunt and post pics of your cat!