Gunner,
I'm sure your 270 set up would work very well for whitetails, and, it would probably work just fine for most African plains game. However, I will mention that most PHs in Africa look for a .30 cal or bigger on plains game since they claim you can usually get a good blood trail with this caliber or above, but not so much with smaller calibers. Don't misread this. They'll let you hunt with whatever you bring, but they'll be waiting for you to mess up with those "little" bullets. I'd personally use the .270 for whatever you want for whitetails, but I'd also keep the 300 and take it to Africa as my "light" rifle. Get a .375 or .458 for your heavy!