You can pay twice the price to feel more confident, or you can use the Core-Lokts and bring home the meat. I've killed a truck load of deer and other game up to moose with CLs. I've also killed a bunch with Nosler Partitions. Two things. Most game doesn't go right down with the NPs, they usually run a ways. But since they almost always give full penetration, there's a good blood trail. Where the NPs serve me very well is in cartridges that are light for the game, e.g. .243Win on Mule Deer. In that case you need a premium bullet, IMHO. But for deer with .300Savage and up, not so much. Another example, .30-06 for Brown Bear. Marginal, so use the best bullet you can buy. Switch to the .375H&H, then bullet construction is not as important. Another place where NPs may be warrented is where you use a lighter bullet in a cartridge to flatten the trajectory. You can sacrifice bullet weight and not lose performance by going to the premium bullet.
Just my experiences, YMMV.
