I had the same happen w/ a 280 handload, but loaded w/ a Sierra 140 game king. The buck was bedded and I rolled him no problem, but he wasn't positioned the way I thought. The shot actually hit the rear leg and went into the chest cavity, but it was just fragments that did the trick. I got lucky on that one, but I think alot has to do w/ shot placement and where and what the bullet hits. I have used the cl bullets in my 7x57 w/o a problem. Jeff