Since originating this topic, I killed my first buffalo in the Zambezi Valley. I loaded a "soft point" (Barnes 450 grain TSX) in the chamber and 450 grain monolithic flat point solids in the magazine for follow on shots. Both attained a muzzle velocity of 2250 fps without pressure signs. A solid, fired into the buff's rear, was later found in its shoulder. That's about 6 feet or so of penetration. That's all anyone needs.
