Another comment from a previous FA owner....the 454 was too much of a good thing for me. Too much recoil at way to fast of a rate. I had a 6" Premier grade in 454. It was sooo accurate. And contrary to Kevin, I loved the grip frame on the Freedom, and I have/had the Super Blackhawk, Bisley, and standard Blackhawk.
If you have the cash to afford one, whatever configuration you choose, I don't think you will be dissappointed. They are just that nice. I am a big fan of the 45LC in a modern revolver. I think you can do many things with it, and it will have plenty of power to spare should you run 335 Hard Cast. But it's your handgun.