I have a number of revolvers in big calibers -- .44 mag, .454 Casull, .475 Linebaugh, .500 Linebaugh, .500 JRH, .50 Alaskan, and hey definitely take some practice to master. I will point out the obvious, but there is no shoulder stock to help you manage recoil with your body, so it really isn't an easy task and requires lots of practice. If you are recoil sensitive, I would suggest a .44 mag or a .45 Colt. Loaded hot, even these are threshold cartridges for many. As was suggested above, try and shoot the calibers in question prior to laying down your hard earned money. There are pleanty of lightly used big-bore revolvers on the market with a half a box of ammo for a reason.
As far as grip frames are concerned, I feel the Bisley-type (like that used on the FA) is the best for heavy kickers -- it's my personal preference. I have a DA revolver in .475, in .454 Casull, and one in .500 LInebaugh and they are downright abusive on the shooter as the recoil comes straight back.
