If "flat shooter" isn't a major factor, I'd go 7-08. I suggested .243 and 80 TTSX because flat trajectory was one of the primary criteria. I've got a Montana in 7-08 slinging the 162AM at over 2700fps, and it may not be nearly as flat shooting out to 400 yards as the .243 and 80TTSX, but it cuts the wind nicely and kills with authority.

A bud just killed a bull moose with this combo a couple of weeks ago, in fact. I was the spotter, and the pair of 162's seriously impressed me, from the bull's reaction to the shots, to the autopsy findings.