I've had the opportunity to see a lot of people who were shot and look at autopsy reports from folks who were shot while doing bad things. Handgun rounds from most legit defensive calibers suck. That being said, they tend to suck about the same. They are also very unpredictable. What I mean is they tend to take paths that no one could predict. Unless you make good contact with the central nervous system, there is no gaurantee of quick stops. Shots that create massive blood loss can be show stoppers, just not immediately.

Gunfights are won because we break the body or break there will to fight. 100ths of an inch in a projectile is way down on the list of what is important.