I vote with ample caliber, momentum, good capacity and expanding bullets. That way if one of your magic beans don't sprout, the rest will probably get you home.
Hey I heard about this cartridge the other day, Forty something or other, which combines the mentioned attributes with room to spare. But it is apparently impossible to shoot well because it 'snaps' the user, rendering him or her helpless.
i only know what the big boys tell me.
