I can shoot the Glock 22 just fine. It's just that I'd rather not have to place a death grip on my handgun to keep from having to reacquire a proper two-handed hold after each shot. I get that with 9mm and .45 ACP Glocks, but not with .40 S&W (at least not with the Gen 4 Glock 22). To me, I need to put a death grip on the Glock 22 Gen 4 with my support hand to keep from needing to reacquire a proper hold from round to round. I can do it, but, like I said, I need to focus on maintaining a death grip with my support hand, and I'd rather not have to do that. That's why I prefer 9mm and .45 ACP over the .40 S&W Glocks.
But, with the new, heavy slide, Gen 5 Glock 22 and 23, I might have to reconsider. I may well give one or the other a shot.
