John Linebaugh carries a model 25 in 45 colt with 300 grain hardcast at around 950 FPS as his bumming around the woods load.
http://www.customsixguns.com/writings/dissolving_the_myth.htmYou should, too.
Or, just get a Redhawk in 45 colt, and shoot same at 1,250 FPS without fear of anything that walks