While I'd like to have one of these in 250, realistically a 22-250 with a 1-8" barrel and shooting 70 or 75gr. pills would be just as effective inside 200 yards, IMHO. The velocity gain of the 22-250 would offset the, probably, 100gr. bullet weight. Some would disagree, but I'd use that combo in a heartbeat. In fact I plan to this fall.