Hand-to-hand?

Don't let those you don't know close with you
Know your surroundings, particularly behind you
Eyes, throat, crotch
Gun trumps knife trumps hands & feet
The better part of valor
Bigger, younger, fitter wins
and best
It looks bad, so I won't go there

A good article for those of us who still get to experience the thrill of being there, but most of us do best having a little healthy paranoia and caution.
And us others have said, being max nasty in a fight not avoided.