The one I have most experience with is the 180 grain .308. We had a lot of problems with them disintegrating. On small animals they still killed, just made a mess. On larger animals it usually took a number of shots to put them on the ground unless we were taking head shots. Despite those problems, we continued to use them because .. I don't know, that was my father's choice, when you're 10-15, you generally shoot what you're handed.
I'm pretty happy with the flat point and round nose interlocks for lever action use. Their handgun bullets are pretty good. I don't use hornadys for any high velocity use other than varmint shooting .. they're very good for that.
Tom
