I'm an Interlock user. My favorite is the no longer made 100gr .257 that's had more one shot, DRT kills on deer than any other bullet/caliber I own. I also use them in my 338, 250gr and my 3006 in 180. That same 180 bullet out of a 300 Weatherby is probably the upper limit for this bullet. Here it is, last one on right, recovered from the ham of an impala shot at approx 80 yards on the point of the shoulder. Traversed the entire animal, shed its core, recovered weight was 79gr