You can't go wrong with the .30-06 and a good 165gr bullet IMO.
True Dat! I'm crass enough to run a 165 grain Hornady Interlock SP in my Browning X-Bolt and 180 grain Hornady Interlock RN in my Remington 7600 Carbine. Didn't shoot anything with them this year, in fact I'm sad to report that I didn't even hunt with the 7600 this year. From what I've seen, a 165/168 grain bullet in a 30-06 knocks the snot out of deer!