I've found that in my rifle H4350 is as good as it gets. RL19 was too slow, and even with 4831sc and 50.6gn in the case behind a 160gn Protected Point Woodleigh bullet, it didn't shoot as well as H4350 did. at the moment I'm pretty happy with Norma Brass, CCI LR primers, 50gn H4350 and a 139gn Hornady SST doing 2,800 at the muzzle. 154gn Hornady Interlocks aren't too shabby either. It was mentioned somewhere here that you should try for a reasonable muzzle velocity, and work your load development around that, not a bad idea as long as accuracy is not compromised.