I use a .270 for rifle elk hunting. It's perfectly adequate. If I had a 375 H&H I'd use it just because! I know two guys who hunt everything from antelope to moose with 338 WM. Thing is, it kills antelope with a nice clean wound channel that drops them right there and works great on the big boys too.
Plus, if you get into jackalope you can feel confident in not being under gunned.
