I have always carried a 1912 cocked and locked. My current carry and nightstand gun is a Wilson Combat EDC-X9 and it has no grip safety just the thumb safety. It is carried cocked and locked. As for carrying a semi auto without a round in the chamber which means you have to rack the slide in an emergency. While drawing your gun in any situation is an aggressive move, racking the slide would seem to me to be even more aggressive. It may not matter but it is something to consider.

Guns don't kill people, it's mostly the bullets