Where are you hunting? How far are your shots?

For me, I use my .338WM the most because I don't get long shots hardly ever. With a 250gr Woodleigh Weldcore or a NPT it's plowed through even on off angled shots. In timber you don't get to pick your shots much so having confidence in deep penetration is nice. Out in the more open areas I've used lot's of different cartridges. Even .257" bullets have worked.

“You never need fear a man, no matter what his size. When danger threatens, call on me, and I will equalize.”
Samuel Colt.

�Common sense is genius dressed up in work clothes.� - Ralph Waldo Emerson