In my lifetime I have shot them with several different 7mm's, an 06, (14) muzzleloader, 300 Bee, and 300 WM, out to and past a laser measured 540 yards. To this day I still feel that there is a noticable difference between the 300 WM and the 7's. I will always favor the 300 WM. But I think the old adage, that you should shoot what you can shoot, and with good bullets, you will do well.