Thirty years of experience here. Big toe. Ankles, knees, knuckles, and a few other places. It can get to kidneys. I can no longer take nsaids due to chronic kidney disease, possibly from nsaid treatment. Only recourse now is copious intake of water (keep your urine straw colored to almost clear), allopurinol daily (I recently had to go back up to 100mg from 50 per day), and stay away from shellfish, asparagus, red wine, dark beer, too much red meat, and everything fun and tasty. I used to take a dose of Joggin in a jug daily but can't find it any more.
