Originally Posted by TimberRunner
Originally Posted by OldHat
Originally Posted by KFWA
two more vaccines are coming onto the market - Johnson & Johnson, which I believe is just one shot, not two, and the Astra Zeneca.

I'm hoping that by June anyone that wants a shot can get one.

It is my understanding that both these are viral vector vaccines. Which means they deliver DNA into your nucleus. They use a carrier virus to do that. The DNA then causes your cells to produce mRNA which in turn produces antigens.

Moderna and Pfizer are both mRNA vaccines which use an LNP as the delivery vehicle to get the mRNA into the cells. These skip the DNA part and just induce your cells to produce antigens.

Do your research folks. I don't know, but I don't want foreign DNA in the nucleus of my cells. Which cells are targeted by the vector virus? How long does the DNA stay in the nucleus? All questions I don't know.


That's what most viruses do, integrate their DNA into your DNA.

It makes sense that a viral vaccine should mimic this process.

Many viruses are RNA viruses. They do not have DNA to integrate. Coronaviruses are RNA viruses. So even in a normal SARS-CoV-2 infection there is no viral DNA in our nucleus. The viral vector vaccines use adenovirus which is a DNA virus. So with a normal infection no DNA in our cells. With a viral vector vaccine new DNA in our cells. I don't know what which cells are targeted by these vaccine or what happens to the co-opted cells.

That said the viruses that do place DNA in our nucleus often result in later disease, herpes comes to mid. Having foreign DNA in my cells is not something I want.

Last edited by OldHat; 01/25/21.