I've shot enough coyotes to have a decent fix on this.
The question of 53 grain VMAX keeps coming up.
Never used it in 22-250 but in .223 they always exit from my model 600. From an 8 twist AR 15 they mostly don't. Twist is important, more so than you might think.
I've used quite a few 40 blitkings and they mostly exit. I really don't trust the 22-250 with fur