I have seen some good off hand 150+ yard shots at coyotes by people that have been doing that all their lives. That's not me. I use whatever rest I can and all my big game rifles have bipods.
For the average hunter, shooting offhand = miss. 4 MOA is a lot and frankly limits your shots to well within 200 yards. Forget varmint hunting without any aids.

I hunted in Wyoming for over 30 years, and the average shot was around 200 yards on any decent deer or antelope. Off hand doesn't cut it.